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Churg–Strauss syndrome
Churg–Strauss syndrome (CSS, also known as eosinophilic granulomatosis with polyangiitis () or allergic granulomatosis) is an autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy). It usually manifests in three stages. The early (prodromal) stage is marked by airway inflammation; almost all patients experience asthma and/or allergic rhinitis. The second stage is characterized by abnormally high numbers of eosinophils (hypereosinophilia), which causes tissue damage, most commonly to the lungs and the digestive tract. The third stage consists of vasculitis, which can eventually lead to cell death and can be life-threatening.
Effective treatment of Churg–Strauss syndrome requires suppression of the immune system with medication. This is typically glucocorticoids followed by other agents such as cyclophosphamide or azathioprine.
The syndrome carries the name of the doctors who first described it in 1951, Jacob Churg and Lotte Strauss.
== Signs and symptoms ==
Churg–Strauss syndrome consists of three stages, but not all patients develop all three stages or progress from one stage to the next in the same order;〔(【引用サイトリンク】url=http://www.mayoclinic.com/health/churg-strauss-syndrome/DS00855/DSECTION=symptoms )〕 whereas some patients may develop severe or life-threatening complications such as gastrointestinal involvement and heart disease, some patients are only mildly affected, ''e.g.'' with skin lesions and nasal polyps. Churg–Strauss syndrome is consequently considered a highly variable condition in terms of its presentation and its course.〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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